SAT-297 PRO-RESOLVING ACTIONS OF LIPOXIN A4 MIMETICS AGAINST DIABETIC NEPHROPATHY

Innate immunity is a key factor for the resolution of inflammation in asthma

The resolution of inflammation is an integral and natural part of the physiological response to tissue injury, infection and allergens or other noxious stimuli. Resolution is now recognised as an active process with highly regulated cellular and biochemical events. Recent discoveries have highlighted that innate inflammatory cells have bimodal effector functions during the inflammatory response...

Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors

Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors Undurti N. Das Phosphodiesterase-5 enzyme inhibitors (PDE-5-Is) such as sildenafil, vardenafil and tadalafil are used in the treatment of male erectile dys-function (ED). Their beneficial action can be attributed to an increase in the intracellular cGMP level due to inhibition of PDE-5 and conse...

Lipoxin A4: a novel anti-inflammatory molecule?

Lipoxin A4 mitigates experimental autoimmune myocarditis

Abstract. – OBJECTIVE: Myocarditis, an acute inflammation disease of the heart, is a potentially lethal disease and can lead to sudden death. This study aims to investigate the therapeutic effect of lipoxin A4 (LXA4) on experimental autoimmune myocarditis (EAM) and to explore the underlying mechanism. MATERIALS AND METHODS: EAM was induced in BALB/c mice by injection of porcine cardiac myosin a...

Novel lipid mediator aspirin-triggered lipoxin A4

Lipoxins (LX) and aspirin-triggered LX (ATL) are eicosanoids generated via transcellular biosynthetic routes during inflammation, that elicit distinct anti-inflammatory and proresolution bioactions, including inhibition of leukocyte-mediated injury, stimulation of macrophage clearance of apoptotic neutrophils, repression of proinflammatory cytokines production, and inhibition of cell proliferat...